関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Cyclopropylamine | HCID 69828 | — |
| 反応物 | 5,7-Dichloropyrazolo[1,5-a]pyrimidine | HCID 11074154 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 5-chloro-N-cyclopropylpyrazolo[1,5-a]pyrimidin-7-amine | HCID 58196606 | 70.5% |
反応手順
To 5,7-dichloropyrazolo[1,5-a]pyrimidine (200 mg, 1.06 mmol) in acetonitrile was added Et3N (148 μl, 1.06 mmol) and cyclopropylamine (75 μl, 1.06 mmol). The reaction was heated at 80° C. overnight. The mixture was concentrated under reduced pressure, dissolved in dichloromethane, and washed with water. The resulting organic layer was dried over Na2SO4 and concentrated under reduced pressure to afford 156 mg of 5-chloro-N-cyclopropylpyrazolo[1,5-a]pyrimidin-7-amine (70% yield). LCMS (M+1=209)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09303033B2 |
|---|
| 出典データセット | uspto-grants-2016_04 |
|---|
| ORD ID | ord-d98b02afbc9e4febba241c61eb4f1985 |
|---|
| 出典メモ | uspto-grants-2016_04 |
|---|
