Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydantoin | HCID 10006 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 5-Chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196647 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178518478 | HCID 178518478 | 33.2% |
Reaction Steps
To 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (400 mg, 1.70 mmol) in EtOH was added hydantoin (186 mg, 1.86 mmol) and pyrrolidine (14 μL, 0.17 mmol). The reaction was stirred at 70° C. over weekend. Precipitate was filtered and air dried to yield 180 mg (33% yield) 5-((5-chloro-7-(cyclopropylamino)pyrazolo-[1,5-a]pyrimidin-3-yl)methylene)imidazolidine-2,4-dione. LCMS (M+1=319)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09303033B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-a4464827b493468a91cddcaea2cc704b |
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| Source note | uspto-grants-2016_04 |
|---|
