HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624831Generated: October 31, 2026
Water → 5-Azido-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde
https://huagongshe.com/reaction/624831
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 5-Chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196647 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Azido-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 86654662 | 75% |
Reaction Steps
To 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (4.0 g, 16.87 mmol) in dimethylformamide was added sodium azide (1.56 g, 23.9 mmol) and the reaction mixture was heated at 80° C. for 8 hrs. Cooled the reaction mixture, added water and white precipitate filtered and dried to yield 5-azido-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (2.95 g, 75% yield). LCMS (M+1=244)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09303033B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-d49d4370bc5c4486848ea2bb2d3b1ea7 |
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| Source note | uspto-grants-2016_04 |
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