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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624840Generated: October 30, 2026

Dimethylamine, hydrochloride → HCID 76281872, compound

https://huagongshe.com/reaction/624840

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylamine, hydrochlorideHCID 10473—
ReactantDiisopropylethylamineHCID 81531—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 71087292—
ProductHCID 76281872HCID 76281872—

Reaction Steps

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with dimethylamine hydrochloride (CAN 506-59-2) in the presence of TBTU and DIEA to give the title compound as light yellow oil; MS (EI): m/e=312.4 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-b8c4943959904c71b997d123e93b3a86
Source noteuspto-grants-2016_04