Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624866Generated: October 25, 2026

Tetrahydrofurfuryl alcohol → 6-((Tetrahydrofuran-2-yl)methoxy)-5-(trifluoromethyl)picolinic acid

https://huagongshe.com/reaction/624866

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofurfuryl alcoholHCID 7360—
ReactantPotassium HydroxideHCID 14797—
Reactant6-Chloro-5-(trifluoromethyl)picolinic acidHCID 70701016—
Product6-((Tetrahydrofuran-2-yl)methoxy)-5-(trifluoromethyl)picolinic acidHCID 71087646—

Reaction Steps

In analogy to the procedure described in Example 4 a), 6-chloro-5-(trifluoromethyl)picolinic acid (CAN 855915-21-8) was reacted with (tetrahydrofuran-2-yl)methanol (CAN 97-99-4) in the presence of potassium hydroxide to yield the title compound as yellow solid; MS (EI): m/e=290.0 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-36267bffa0e54c9aab12d608f074bb6f
Source noteuspto-grants-2016_04