HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(1,1-Dimethylethyl)benzenemethanamine → 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid benzyl-tert-butyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(1,1-Dimethylethyl)benzenemethanamine | HCID 76908 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid | HCID 71087292 | — |
| Product | 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid benzyl-tert-butyl-amide | HCID 76283583 | — |
Reaction Steps
In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with N-benzyl-2-methylpropan-2-amine (CAN 3378-72-1) in the presence of TBTU and DIEA to obtain the title compound as colorless solid; MS (EI): m/e=430.5 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-7e033d80a5864b97ae1a6f4a102485a8 |
| Source note | uspto-grants-2016_04 |