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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624882Generated: October 31, 2026

Diisopropylethylamine → HCID 76283836, compound

https://huagongshe.com/reaction/624882

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant1104383-07-4HCID 67100683—
Reactant6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 71087292—
ProductHCID 76283836HCID 76283836—

Reaction Steps

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with 3,3-dimethylpiperazin-2-one hydrochloride (CAN 907973-05-1) in the presence of TBTU and DIEA to obtain the title compound as colorless solid; MS (EI): m/e=423.4 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-73b1bf191d40429cadf0e8c91b8f3436
Source noteuspto-grants-2016_04