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Methyl iodide → (+)-6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid methyl-(3-methyl-1-pyridazin-3-yl-butyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (3-methyl-1-pyridazin-3-yl-butyl)-amide | HCID 71105703 | — |
| 生成物 | (+)-6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid methyl-(3-methyl-1-pyridazin-3-yl-butyl)-amide | HCID 90203545 | — |
反応手順
In analogy to the procure described in Example 16 b), (+)-6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (3-methyl-1-pyridazin-3-yl-butyl)-amide was reacted with methyl iodide (CAN 74-88-4) in the presence of sodium hydride to give the title compound as colorless oil; MS (EI): m/e=446.2 [MH]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09303012B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-137ea82a271b4e6693405bd5caa7e0d6 |
| 出典メモ | uspto-grants-2016_04 |