돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 624905생성일: 2026년 10월 25일

Diisopropylethylamine → [5-Cyclopropyl-6-(4-fluoro-benzyl)-pyridin-2-yl]-(4,4-dimethyl-piperidin-1-yl)-methanone

https://huagongshe.com/reaction/624905

반응식

참여 물질

역할이름HCID투입량
반응물DiisopropylethylamineHCID 81531—
반응물4,4-DimethylpiperidineHCID 138100—
반응물O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
반응물5-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acidHCID 71087698—
생성물[5-Cyclopropyl-6-(4-fluoro-benzyl)-pyridin-2-yl]-(4,4-dimethyl-piperidin-1-yl)-methanoneHCID 76284102—

반응 단계

In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid (Example 5 g)) was reacted with 4,4-dimethyl-piperidine (4045-30-1) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=367.5 [MH+].

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09303012B2
출처 데이터셋uspto-grants-2016_04
ORD IDord-664291187ca44503a70e115886a0c74e
출처 메모uspto-grants-2016_04