Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624909Generated: October 29, 2026

Diisopropylethylamine → HCID 76282375, compound

https://huagongshe.com/reaction/624909

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
Reactant(2R)-2-(Methoxymethyl)pyrrolidineHCID 671216—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 71087292—
ProductHCID 76282375HCID 76282375—

Reaction Steps

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with (R)-2-(methoxymethyl)pyrrolidine (84025-81-0) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=382.5 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-673e89631404450cb137afee1e625e85
Source noteuspto-grants-2016_04