HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Dimethyl oxazolidine → (6-Cyclopropylmethoxy-5-trifluoromethoxy-pyridin-2-yl)-(4,4-dimethyl-oxazolidin-3-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Dimethyl oxazolidine | HCID 62010 | — |
| Reactant | 6-Cyclopropylmethoxy-5-trifluoromethoxy-pyridine-2-carboxylic acid | HCID 90202574 | — |
| Reactant | 6-Chloro-5-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 90202609 | — |
| Product | (6-Cyclopropylmethoxy-5-trifluoromethoxy-pyridin-2-yl)-(4,4-dimethyl-oxazolidin-3-yl)-methanone | HCID 76282370 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 47 b, using the mixture of 6-cyclopropylmethoxy-5-trifluoromethoxy-pyridine-2-carboxylic acid and 6-chloro-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 47 a, 50 mg, 180 μmol) and 4,4-dimethyl-oxazolidine (CAN 51200-87-4; 28.4 μl (75%), 198 μmol) as starting materials and isolated (24 mg, 37%) as colorless oil; LC-MS (UV peak area, ESI) 100%, 361.1370 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-0860312ac4f74f5186e6d84652ce2168 |
| Source note | uspto-grants-2016_04 |