化工社化工社 化学情報印刷レポート · 研究参考用
4,4-Dimethyl oxazolidine → (6-Chloro-5-cyclopropylmethoxy-pyridin-2-yl)-(4,4-dimethyl-oxazolidin-3-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,4-Dimethyl oxazolidine | HCID 62010 | — |
| 反応物 | 6-Cyclopropylmethoxy-5-trifluoromethoxy-pyridine-2-carboxylic acid | HCID 90202574 | — |
| 反応物 | 6-Chloro-5-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 90202609 | — |
| 生成物 | (6-Chloro-5-cyclopropylmethoxy-pyridin-2-yl)-(4,4-dimethyl-oxazolidin-3-yl)-methanone | HCID 76284105 | — |
反応手順
The title compound was synthesized in analogy to Example 47 b, using the mixture of 6-cyclopropylmethoxy-5-trifluoromethoxy-pyridine-2-carboxylic acid and 6-chloro-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 47 a, 50 mg, 180 μmol) and 4,4-dimethyl-oxazolidine (CAN 51200-87-4; 28.4 μl (75%), 198 μmol) as starting materials and isolated (13 mg, 23%) as colorless oil; LC-MS (UV peak area, ESI) 100%, 311.1158 [MH+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09303012B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-0de36d9c7245411c95f5cb90258b9047 |
| 出典メモ | uspto-grants-2016_04 |