1-[4-(Cyclopropylamino)piperidin-1-yl]ethan-1-one → HCID 76284106, compound

HRID 624913Notes

Reaction equation

HRID 624913 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[CH:21]1([NH:24][CH:25]2[CH2:30][CH2:29][N:28]([C:31](=[O:33])[CH3:32])[CH2:27][CH2:26]2)[CH2:23][CH2:22]1>>[C:31]([N:28]1[CH2:27][CH2:26][CH:25]([N:24]([CH:21]2[CH2:23][CH2:22]2)[C:12]([C:10]2[CH:9]=[CH:8][C:7]([N:15]3[CH2:18][C:17]([F:20])([F:19])[CH2:16]3)=[C:6]([O:5][CH2:4][CH:1]3[CH2:2][CH2:3]3)[N:11]=2)=[O:14])[CH2:30][CH2:29]1)(=[O:33])[CH3:32]

Participants

3

Reactant 2

HCID 27352411-[4-(Cyclopropylamino)piperidin-1-yl]ethan-1-oneHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 76284106HCID 76284106, compound

Procedure

The title compound was synthesized in analogy to Example 47 b), using 6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid and 1-(4-(cyclopropylamino)piperidin-1-yl)ethanone (CAS 387358-46-5) as starting materials and isolated as colorless oil. MS (EI): m/e=449.6 [MH+].

Workup

  1. customisolated as colorless oil

Sources & evidence

ORD record
ord-3d4af8108a184355ad3c5483c18794ed
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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