HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | [3-(Trifluoromethyl)-1,2,4-oxadiazol-5-yl]methanamine hydrochloride | HCID 66687518 | — |
| Reactant | 6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid | HCID 71087292 | — |
| Product | 6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)picolinamide | HCID 90203747 | — |
Reaction Steps
In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b) was reacted with C-(3-trifluoromethyl-[1,2,4]oxadiazol-5-yl)-methyl amine hydrochloride (CAS 944905-93-5) in the presence of TBTU and DIEA to give the title compound as white solid; MS (EI): m/e=434.5 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-5f3ddd22e2d4470280ee174bf08b6d6f |
| Source note | uspto-grants-2016_04 |