29885-95-8 → HCID 90203946, compound

HRID 624915Notes

Reaction equation

HRID 624915 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.FC(F)(F)C(O)=O.[CH3:28][NH:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH3:28][N:29]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14]

Participants

3

Reactant 2

HCID 1180623829885-95-8HCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 90203946HCID 90203946, compound

Procedure

The title compound was synthesized in analogy to Example 47b), using 6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid (Example 1 b) and N-methylaniline 2,2,2-trifluoroacetate (CAS 29885-95-8) as starting materials and isolated as colorless oil. MS (EI): m/e=374.5 [MH+].

Workup

  1. customisolated as colorless oil

Sources & evidence

ORD record
ord-4239e7a6475d416da1e5c97294c82ade
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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