6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid → HCID 90204473, compound

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Reaction Steps

The title compound was synthesized in analogy to Example 47b), using 6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid (Example 1 b) and N,1,4-trimethyl-1H-pyrazol-3-amine (which can be prepared from 3-formylamino-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester CAN 114936-04-8 via reduction with lithium aluminum hydride in diethyl ether at ambient temperature) as starting materials and isolated as colorless oil. MS (EI): m/e=392.5 [MH+].

Provenance & Evidence