2,2-Dimethylmorpholine → HCID 76282372, compound

HRID 624918Notes

Reaction equation

HRID 624918 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[CH3:21][C:22]1([CH3:28])[O:27][CH2:26][CH2:25][NH:24][CH2:23]1>>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([N:24]3[CH2:25][CH2:26][O:27][C:22]([CH3:28])([CH3:21])[CH2:23]3)=[O:14])[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 189596742,2-DimethylmorpholineHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 76282372HCID 76282372, compound

Procedure

The title compound was synthesized in analogy to Example 47b), using 6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid (Example 1 b) and 2,2-dimethylmorpholine (CAS 147688-58-2) as starting materials and isolated as colorless oil. MS (EI): m/e=382.5 [MH+].

Workup

  1. customisolated as colorless oil

Sources & evidence

ORD record
ord-4eddf0e7b7cd4893a9c3313effa1607b
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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