huagongshe.com
HRID624931

反应详情

EQUATION

反应方程式

HRID 624931 的结构方程式

REACTANTS

反应物

2
结构：Cl.NC(=O)[C@@H]1C[C@H](F)CN1
HCID45158917

(4S)-4-Fluoro-L-prolinamide--hydrogen chloride (1/1)

C5H10ClFN2O

结构：O=C(O)c1ccc(C2CC2)c(OCC2CC2)n1
HCID71087346

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)[C@@H]1C[C@H](F)CN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1
HCID90203853

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 50 mg, 214 μmol) and (2S,4S)-4-fluoro-2-pyrrolidinecarboxamide hydrochloride (1:1) (CAN 426844-23-7; 40 mg, 236 μmol) as starting materials and isolated (68 mg, 91%) as off-white solid; LC-MS (UV peak area, ESI) 100%, 348.1721 [MH+].

WORKUP

后处理

  1. customisolated (68 mg, 91%) as off-white solid