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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624935Generated: October 30, 2026

Diisopropylethylamine → HCID 76284632, compound

https://huagongshe.com/reaction/624935

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 71087292—
Reactant1,8-Diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester hydrochlorideHCID 90204144—
ProductHCID 76284632HCID 76284632—

Reaction Steps

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with tert-butyl 1,8-diazaspiro[4.5]decane-8-carboxylate hydrochloride (851325-42-3) in the presence of TBTU and DIEA to obtain the title compound as yellow oil; MS (EI): m/e=507.6 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-7a5cb0761f914131825aaf582b16b7b1
Source noteuspto-grants-2016_04