HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4,4-Difluoropyrrolidine-2-carboxamide hydrochloride → (R)-1-[5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carbonyl]-4,4-difluoro-pyrrolidine-2-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4,4-Difluoropyrrolidine-2-carboxamide hydrochloride | HCID 45158907 | — |
| Reactant | 5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid | HCID 86674787 | — |
| Product | (R)-1-[5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carbonyl]-4,4-difluoro-pyrrolidine-2-carboxylic acid amide | HCID 76280801 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid (30 mg, 96 μmol) and (2R)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (CAN 1315053-41-8; 19.8 mg, 106 μmol) as starting materials and isolated (38 mg, 89%) as white solid; LC-MS (UV peak area, ESI) 97%, 444.1155 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-571be7060ceb4d15b1745ad91db30453 |
| Source note | uspto-grants-2016_04 |