4-Thiazolidinecarboxamide → HCID 76280804, compound

HRID 624958Notes

Reaction equation

HRID 624958 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[S:18]1[CH2:22][CH:21]([C:23]([NH2:25])=[O:24])[NH:20][CH2:19]1>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([N:20]3[CH:21]([C:23]([NH2:25])=[O:24])[CH2:22][S:18][CH2:19]3)=[O:17])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 99641014-ThiazolidinecarboxamideHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 76280804HCID 76280804, compound

Procedure

The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 100 mg, 429 μmol) and 4-thiazolidinecarboxamide (CAN 103749-87-7, 62.3 mg, 472 μmol) as starting materials and isolated (114 mg, 77%) as white solid; LC-MS (UV peak area, ESI) 100%, 348.1377 [MH+].

Workup

  1. customisolated (114 mg, 77%) as white solid

Sources & evidence

ORD record
ord-b6df4d90c15b4b1b85de68a7779c03d5
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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