Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624963Generated: November 1, 2026

Diisopropylethylamine → HCID 76280807, compound

https://huagongshe.com/reaction/624963

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant3,3-Difluoroazetidine hydrochlorideHCID 2758247—
Reactant6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 71087292—
ProductHCID 76280807HCID 76280807—

Reaction Steps

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7) in the presence of TBTU and DIEA to obtain the title compound as colorless solid; MS (EI): m/e=360.4 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-a8d4cf5812fc4533af14dbc94b2b0023
Source noteuspto-grants-2016_04