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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624975Generated: October 25, 2026

Diisopropylethylamine → HCID 76281071, compound

https://huagongshe.com/reaction/624975

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant3,3,4,4-Tetrafluoropyrrolidine HydrochlorideHCID 22645920—
Reactant6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 71087292—
ProductHCID 76281071HCID 76281071—

Reaction Steps

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with 3,3,4,4-tetrafluoropyrrolidine hydrochloride (1810-13-5) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=410.5 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-64db432c9b7b40e8b62214dfce537462
Source noteuspto-grants-2016_04