HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4R)-4-Fluoro-L-prolinamide--hydrogen chloride (1/1) → HCID 90215317, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4R)-4-Fluoro-L-prolinamide--hydrogen chloride (1/1) | HCID 67034973 | — |
| Reactant | 6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid | HCID 71087292 | — |
| Product | HCID 90215317 | HCID 90215317 | 49% |
Reaction Steps
In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b, 25 mg, 87.9 μmol) was reacted with (2S,4R)-4-fluoropyrrolidine-2-carboxamide hydrochloride (CAN 796884-06-5, 17.8 mg, 106 μmol) to obtain the title compound (17 mg, 49%) as white solid; MS (EI): m/e=399.4 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-f6bb6d780b7f496b84d3ebb0f0ab1232 |
| Source note | uspto-grants-2016_04 |