反应详情

温度

110 °C

Under a nitrogen atmosphere, 3-methoxyazetidine (38 mg, 0.44 mmol), BINAP (23 mg, 0.037 mmol), Pd2(dba)3 (17 mg, 0.02 mmol) and Cs2CO3 (240 mg, 0.735 mmol) were added to a solution of 5-bromo-6-(cyclopropylmethoxy)pyridine-2-carboxylic acid (CAN 1415898-37-1, 100 mg, 0.37 mmol) in toluene (4 mL). The reaction mixture was stirred overnight at 110° C. and then concentrated under reduced pressure. The residue was dissolved in water and extracted with ethyl acetate (30 mL). The aqueous layer was adjusted to pH 2 by addition of 1N HCl. The resulting precipitate was collected by filtration and dried in vacuo. Chromatographical purification over silica gel using petroleum ether/ethyl acetate=1/2 provided the title compound (35 mg, 34%) as a yellow solid, LC-MS: 265.2 [MH+].

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in water
3. extractionextracted with ethyl acetate (30 mL)
4. additionThe aqueous layer was adjusted to pH 2 by addition of 1N HCl
5. filtrationThe resulting precipitate was collected by filtration
6. customdried in vacuo
7. customChromatographical purification over silica gel