HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Cyclopropylmethoxy)-5-(3-methoxyazetidin-1-yl)picolinic acid → 3-[6-(Cyclopropylmethoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]-1,1-dioxo-1,3-thiazolidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Cyclopropylmethoxy)-5-(3-methoxyazetidin-1-yl)picolinic acid | HCID 90203453 | — |
| Reactant | 1,1-Dioxo-1,3-thiazolidine-4-carboxamide hydrochloride | HCID 90203843 | — |
| Product | 3-[6-(Cyclopropylmethoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]-1,1-dioxo-1,3-thiazolidine-4-carboxamide | HCID 90203568 | 33% |
Reaction Steps
In analogy to the procedure described in Example 127 e), 6-(cyclopropylmethoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxylic acid (Example 128 a, 30 mg, 108 μmol) was reacted with 1,1-dioxo-1,3-thiazolidine-4-carboxamide hydrochloride (Example 127 d, 26.0 mg, 129 μmol) to give the title compound (15 mg, 33%) as off-white solid, MS (EI): m/e=425.5 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-27f172082ca247ac89f97b2f5e1536df |
| Source note | uspto-grants-2016_04 |