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HRID624990

反应详情

EQUATION

反应方程式

HRID 624990 的结构方程式

REACTANTS

反应物

2
结构：Cl.NC(=O)[C@@H]1CC(F)(F)CN1
HCID45158909

4,4-Difluoro-L-prolinamide--hydrogen chloride (1/1)

C5H9ClF2N2O

结构：O=C(O)c1ccc(C2(O)CCC2)c(OCC2CC2)n1
HCID71087611

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(C2(O)CCC2)c(OCC2CC2)n1
HCID76281331

未命名化合物

收率 26.6%

PROCEDURE

实验过程

In analogy to the procedure described in Example 127 e), 6-(cyclopropylmethoxy)-5-(1-hydroxycyclobutyl)pyridine-2-carboxylic acid (CAN 1415899-53-4, 15 mg, 57 μmol) was reacted with (S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (CAN 426844-51-1, 10.6 mg, 57 μmol) to give the title compound (6 mg, 21%) as light yellow oil, LC-MS (UV peak area, ESI) 100%, 396.1740 [MH+].