HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Cyclopropylmethoxy-5-(1-hydroxy-cyclobutyl)-pyridine-2-carboxylic acid → 3-[6-(Cyclopropylmethoxy)-5-(1-hydroxycyclobutyl)pyridine-2-carbonyl]-1,1-dioxo-1,3-thiazolidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Cyclopropylmethoxy-5-(1-hydroxy-cyclobutyl)-pyridine-2-carboxylic acid | HCID 71087611 | — |
| Reactant | HCID 90203843 | HCID 90203843 | — |
| Product | 3-[6-(Cyclopropylmethoxy)-5-(1-hydroxycyclobutyl)pyridine-2-carbonyl]-1,1-dioxo-1,3-thiazolidine-4-carboxamide | HCID 90203651 | 9% |
Reaction Steps
In analogy to the procedure described in Example 127 e), 6-(cyclopropylmethoxy)-5-(1-hydroxycyclobutyl)pyridine-2-carboxylic acid (CAN 1415899-53-4, 50 mg, 190 μmol) was reacted with 1,1-dioxo-1,3-thiazolidine-4-carboxamide hydrochloride (Example 127 d, 45.7 mg, 228 μmol) to give the title compound (7 mg, 8%) as colorless oil, MS (EI): m/e=410.5 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-bddc64fb0e4c4394a40cf6d5872c3e77 |
| Source note | uspto-grants-2016_04 |