HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Diethylamino)sulfur trifluoride → 2-Chloro-3-(3-fluorooxetan-3-yl)-6-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Diethylamino)sulfur trifluoride | HCID 123472 | — |
| Reactant | 3-(2-Chloro-6-methylpyridin-3-yl)oxetan-3-ol | HCID 90202624 | — |
| Product | 2-Chloro-3-(3-fluorooxetan-3-yl)-6-methylpyridine | HCID 90202646 | 56% |
Reaction Steps
In analogy to the procedure described in Example 130 b), 3-(2-chloro-6-methylpyridin-3-yl)oxetan-3-ol (Example 134 a, 1.5 g, 7.51 mmol) was reacted with diethylaminosulfur trifluoride to obtain the title compound (850 mg, 56%) as colorless liquid, MS (ESI): m/e=202.1 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-d417c9c2bcfc4bd7a56a699dfc14af04 |
| Source note | uspto-grants-2016_04 |