HRID625005

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID45158909

4,4-Difluoro-L-prolinamide--hydrogen chloride (1/1)

C5H9ClF2N2O

HCID90202732

未命名化合物

PRODUCTS

生成物

结构：NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(C2(F)COC2)c(OCC2CC2)n1

HCID90204187

未命名化合物

收率 54%

PROCEDURE

实验过程

In analogy to the procedure described in Example 127 e), 6-(cyclopropylmethoxy)-5-(3-fluorooxetan-3-yl)pyridine-2-carboxylic acid (Example 134 f, 25 mg, 93.5 μmol) was reacted with (S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (CAN 426844-51-1, 20.9 mg, 112 μmol) to give the title compound (20 mg, 54%) as colorless oil, MS (EI): m/e=400.2 [MH+].