Ammonia → HCID 90203364, compound

HRID 625006Notes

Reaction equation

HRID 625006 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH:14]([C:15]([OH:17])=O)[CH2:13][C:10]2([CH2:12][CH2:11]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:18]>>[C:15]([CH:14]1[CH2:13][C:10]2([CH2:12][CH2:11]2)[CH2:9][N:8]1[C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])(=[O:17])[NH2:18]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 666205945-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester

Product 1

HCID 90203364HCID 90203364, compoundYield 78%

Procedure

In analogy to the procedure described in Example 127 c), 5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid (CAN 1454843-77-6, 112 mg, 464 μmol) was condensed with ammonia to give the title compound (87 mg, 78%) as colorless liquid, MS (EI): m/e=240.0 [M+].

Sources & evidence

ORD record
ord-abd7e8ad4bfd46fcaa945a1958fe69bf
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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