6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid → HCID 118451454, compound

Participants

Reaction Steps

In analogy to the procedure described in Example 127 e), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b, 50 mg, 176 μmol) was reacted with (2S)-4-hydroxy-4-methylpyrrolidine-2-carboxamide hydrochloride (Example 132 b, 39.7 mg, 176 μmol) and purified by chiral HPLC to obtain the title compound (8 mg, 10%) as white solid, LC-MS (UV peak area, ESI) 93%, 411.1854 [MH+].

Provenance & Evidence