HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → HCID 90204221, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 71087346 | — |
| Reactant | 1613292-86-6 | HCID 90204416 | — |
| Product | HCID 90204221 | HCID 90204221 | 49% |
Reaction Steps
In analogy to the procedure described in Example 127 e), 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 20 mg, 85.7 μmol) was reacted with 2,2,2-trifluoro-1-(pyrrolidin-3-yl)ethanol hydrochloride (CAN of corresponding free base: 943906-23-8, 21.2 mg, 103 μmol) to obtain the title compound (16 mg, 49%) as colorless liquid, MS (EI): m/e=385.3 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-f3573c84e5a4466982dd432b1509e2ce |
| Source note | uspto-grants-2016_04 |