HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)azetidin-3-ol hydrochloride → [5-Cyclopropyl-6-(cyclopropylmethoxy)pyridin-2-yl]-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)azetidin-3-ol hydrochloride | HCID 46735152 | — |
| Reactant | 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 71087346 | — |
| Product | [5-Cyclopropyl-6-(cyclopropylmethoxy)pyridin-2-yl]-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]methanone | HCID 76281602 | 23% |
Reaction Steps
In analogy to the procedure described in Example 127 e), 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 20 mg, 85.7 μmol) was reacted with 3-(trifluoromethyl)azetidin-3-ol hydrochloride (CAN 848192-96-1, 18.3 mg, 103 μmol) to obtain the title compound (7 mg, 23%) as colorless oil, MS (EI): m/e=357.3 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-5eff8f7bc1bb47ed929fe1196664857f |
| Source note | uspto-grants-2016_04 |