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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 625023Generated: October 31, 2026

(3-fluoroazetidin-3-yl)Methanol → HCID 76281604, compound

https://huagongshe.com/reaction/625023

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-fluoroazetidin-3-yl)MethanolHCID 53302277—
Reactant6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 71087292—
ProductHCID 76281604HCID 7628160442.1%

Reaction Steps

In analogy to the procedure described in Example 127 e), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b, 20 mg, 70.4 μmol) was reacted with (3-fluoroazetidin-3-yl)methanol (CAN 1268520-93-9, 8.87 mg, 84.4 μmol) to obtain the title compound (11 mg, 42%) as colorless liquid, MS (ESI): m/e=372.2 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-a201bf127794411fb27277c20b73665b
Source noteuspto-grants-2016_04