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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 625024Generated: November 1, 2026

6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid → HCID 76281871, compound

https://huagongshe.com/reaction/625024

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 71087292—
Reactant3-Fluoro-3-Methylazetidine hydrochlorideHCID 71757905—
ProductHCID 76281871HCID 7628187124%

Reaction Steps

In analogy to the procedure described in Example 127 e), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b, 20 mg, 70.4 μmol) was reacted with 3-fluoro-3-methylazetidine hydrochloride (CAN 1427379-42-7, 10.6 mg, 84.4 μmol) to obtain the title compound (6 mg, 24%) as off-white solid, MS (ESI): m/e=356.2 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-14a62a4ccfdb4dc6adce4374447f6e87
Source noteuspto-grants-2016_04