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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 625025Generated: October 31, 2026

3-Cyclopropyl-3-fluoroazetidine hydrochloride → HCID 76281605, compound

https://huagongshe.com/reaction/625025

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Cyclopropyl-3-fluoroazetidine hydrochlorideHCID 66589642—
Reactant6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 71087292—
ProductHCID 76281605HCID 7628160530%

Reaction Steps

In analogy to the procedure described in Example 127 e), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b, 20 mg, 70.4 μmol) was reacted with 3-cyclopropyl-3-fluoroazetidine hydrochloride (CAN 936548-77-5, 12.8 mg, 84.4 μmol) to obtain the title compound (8 mg, 30%) as colorless liquid, MS (ESI): m/e=382.3 [MH+].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303012B2
Source datasetuspto-grants-2016_04
ORD IDord-cbdac2a12aa04755acf02f8190642950
Source noteuspto-grants-2016_04