6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid → HCID 90203742, compound

Participants

Reaction Steps

In analogy to the procedure described in Example 127 e), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b, 80 mg, 281 μmol) was reacted with a mixture of 5-azaspiro[2.4]heptane-4-carboxamide hydrochloride and 5-azaspiro[2.4]heptane-6-carboxamide hydrochloride (Example 151 d, 59.7 mg, 338 μmol) to obtain the title compound after preparative chiral HPLC (22 mg, 19%) as off-white solid, MS (ESI): m/e=407.3 [MH+].

Provenance & Evidence