Hydrochloric Acid → HCID 24950908, compound

Participants

Reaction Steps

HCl (4M, 1 mL) was added to a solution of (2R)-tert-butyl 3-(4-chlorophenyl)-1-(4-(5-methyl-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate (0.10 g, 0.18 mmol) in DCM (5 mL) and MeOH (1 mL). The mixture was stirred at room temperature for 6 hours. The solvent was removed to afford (2R)-2-amino-3-(4-chlorophenyl)-1-(4-(5-methyl-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one as the di-hydrochloride salt. LCMS: 450.1 [M+H+] (APCI+).

Provenance & Evidence