Hydrochloric Acid → HCID 24950750, compound

Participants

Reaction Steps

HCl (4M, 1 mL) was added to a solution of 3-(4-chlorophenyl)-1-(4-(5-methyl-6-oxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate (0.050 g, 0.091 mmol) in DCM (4 mL) and MeOH (1 mL). The mixture was stirred at room temperature for 6 hours. The solvent was removed to afford (2R)-2-amino-3-(4-chlorophenyl)-1-(4-(5-methyl-6-oxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one as the di-hydrochloride salt (0.40 g). LCMS: 450.1 [M+H+] (APCI+).

Provenance & Evidence