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HRID625147

反应详情

EQUATION

反应方程式

HRID 625147 的结构方程式

REACTANTS

反应物

2
结构：NCCOCCOCCN
HCID70248

2,2'-[Ethane-1,2-diylbis(oxy)]diethanamine

C6H16N2O2

结构：CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4CC(OC(=O)Cl)CC[C@]4(C)C3CC[C@@]21C
HCID54236888

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)NCCOCCOCCN)CC[C@]4(C)[C@H]3CC[C@]12C
HCID67367938

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

3 次

PROCEDURE

实验过程

A solution of cholesteryl chloroformate (1 g, 2.23 mmol) in 25 mL dichloromethane was added dropwise under stirring to a solution of 2,2′-(ethylenedioxy)bis-(ethylamine) (495 mg, 3.34 mmol) in 75 mL dichloromethane. The reaction was stirred overnight at room temperature. The reaction was diluted with dichloromethane and extracted with water. The organic extract was dried over anhydrous MgSO4 dihydrate, filtered and evaporated. After purification on amino-modified silica gel (eluent: MeCl2→MeCl2/MeOH=975:25 v/v) the product (615 mg) was obtained as a white, waxy solid. MS (ISP): (M+H) 561.5

WORKUP

后处理

  1. extractionextracted with water
  2. extractionThe organic extract
  3. dry with materialwas dried over anhydrous MgSO4 dihydrate
  4. filtrationfiltered
  5. customevaporated
  6. customAfter purification on amino-modified silica gel (eluent: MeCl2→MeCl2/MeOH=975:25 v/v) the product (615 mg)
  7. customwas obtained as a white, waxy solid