Carbon Dioxide → HCID 86664460, compound

HRID 625148Notes

Reaction equation

HRID 625148 reaction equation
[CH2:1]=[CH:2][CH2:3][NH2:4].[CH2:5]1[O:7][CH:6]1[CH2:8][Cl:9].Cl.[OH-:11].[Na+].[C:13](=[O:15])=[O:14]>O>[CH2:1]=[CH:2][CH2:3][NH3+:4].[CH2:5]1[O:7][CH:6]1[CH2:8][Cl:9].[C:13]([O-:15])([OH:14])=[O:11].[C:13](=[O:7])([OH:15])[O-:14]

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 14798Sodium HydroxideHCID 159247152751-57-0

Product 1

HCID 86664460HCID 86664460, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
36 °C

Procedure

1.4 kg of water is loaded into a 2 liter glass reactor. The temperature is set to 35° C. and 100 g of sevelamer hydrochloride is added in portions, stirring the mixture. A solution of 30% sodium hydroxide is then added until pH 12 is reached (around 71 g) and gaseous carbon dioxide is bubbled through. The temperature is maintained at 35-37° C. until pH 7.2 is reached. The mixture is maintained at 35° C. under stirring for 2 hours and if necessary further carbon dioxide is bubbled through until the pH is stabilized at 7.2. The suspension is filtered, the solid washed repeatedly with water to eliminate as much of the residual chlorine as possible. The solid thus obtained is dried and ground.

Workup

  1. customis set to 35° C.
  2. customis bubbled through
  3. temperatureThe mixture is maintained at 35° C.
  4. stirringunder stirring for 2 hours and if necessary further carbon dioxide
  5. customis bubbled through until the pH
  6. filtrationThe suspension is filtered
  7. washthe solid washed repeatedly with water
  8. customThe solid thus obtained
  9. customis dried

Sources & evidence

ORD record
ord-f50be46cccac42c1850d7dc7f04c44c2
Source dataset
uspto-grants-2016_04
Patent number
US09303105B2

Reaction notes

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