Water → HCID 86664460, compound

Temperature

36 °C

1.4 kg of water is loaded into a 2 liter glass reactor. The temperature is set to 35° C. and 100 g of sevelamer hydrochloride is added in portions, stirring the mixture. A solution of 30% sodium hydroxide is then added until pH 12 is reached (around 71 g). The suspension is maintained at 35-37° C. under stirring for 40 minutes and then filtered, the wet solid is resuspended in 800 ml of distilled water and stirred for two hours at room temperature. The solid is then filtered and washed with distilled water. The solid is loaded into a fluid bed dryer at 50° C. for three hours, after which a carbon dioxide stream is passed through the solid until obtaining an internal pressure of around 40000 Pa. The flow is maintained until the pressure decreases. Finally, the drier is maintained under vacuum and the temperature is raised to 60° C. for 72 hours. Sevelamer carbonate/bicarbonate is thus obtained.

1. customis set to 35° C.
2. stirringunder stirring for 40 minutes
3. filtrationfiltered
4. stirringstirred for two hours at room temperature
5. filtrationThe solid is then filtered
6. washwashed with distilled water
7. customuntil obtaining an internal pressure of around 40000 Pa
8. temperatureThe flow is maintained until the pressure
9. temperatureFinally, the drier is maintained under vacuum
10. temperaturethe temperature is raised to 60° C. for 72 hours

ORD record

ord-0716c479df904a03b6a6a6a419a0a118

Source dataset

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09303105B2