Cesium carbonate → 5-(4-Methoxy-3-(2-oxo-2-((2-oxotetrahydrofuran-3-yl)oxy)ethyl)phenyl)-dibenzothiophenium iodide

Participants

Reaction Conditions

Reaction Steps

5-(3-(carboxymethyl)-4-methoxyphenyl)-dibenzothiophenium iodide (50 g, 105 mmol), 3-bromodihydrofuran-2(3H)-one (17.3 g, 105 mmol), and cesium carbonate (68.3 g, 210 mmol) are dissolved in DMF (400 mL) and stirred at 25° C. for 4 h. The reaction mixture is quenched with water (1 L), extracted with DCM (2×400 mL), the combined organic layers washed with water (4×500 mL), concentrated to a viscous oil and precipitated from MTBE (2 L) to afford the title compound as a white solid.

Provenance & Evidence