HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 625230Generated: October 26, 2026
3-(Trifluoromethyl)aniline → 6-(2-nitro-5-(piperidin-1-yl)phenyl)-N-(3-(trifluoromethyl)phenyl)-pyrimidin-4-amine
https://huagongshe.com/reaction/625230
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Reactant | 4-Chloro-6-(2-nitro-5-(piperidin-1-yl)phenyl)pyrimidine | HCID 86705928 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(2-nitro-5-(piperidin-1-yl)phenyl)-N-(3-(trifluoromethyl)phenyl)-pyrimidin-4-amine | HCID 66587938 | 74.5% |
Reaction Steps
A solution of 15 mg of 3-(trifluoromethyl)aniline and 27 mg intermediate 3.1b in 1 mL of DMF was treated with 1 drop of concentrated hydrochloric acid and heated to 90° C. for 1 h. The solution was cooled and partitioned between ethyl acetate and water. The organic extracts were washed with brine and dried over Na2SO4. The solvent was evaporated at reduced pressure to give 28 mg of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09301951B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-cbfee6f6a36c40478f6929beee1ea594 |
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| Source note | uspto-grants-2016_04 |
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