4-Acetamidopiperidine → 2-(2-(3-(4-Acetamidopiperidine-1-carbonyl)benzamido)-5-(piperidin-1-yl)phenyl)-N-(3-(trifluoromethyl)benzyl)isonicotinamide

Participants

Reaction Steps

This compound was prepared from 3-((2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzoic acid 4.1e using the procedure described for the preparation of N1-(2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)-4-(piperidin-1-yl)phenyl)-N3-(3-(2-methoxyethylamino)-3-oxopropyl)-N3-methylisophthalamide 4.2. N-(piperidin-4-yl)acetamide was used as the amine component in this coupling. 1H-NMR (300 MHz, CD3OD, ppm): δ 8.98 (d, J=3.5 Hz, 1H), 8.85 (d, J=9.0 Hz, 1H), 8.47 (s, 1H), 8.24 (d, J=2.4 Hz, 1H), 8.12˜8.09 (m, 2H), 7.90˜7.88 (m, 1H), 7.77˜7.68 (m, 5H), 6.62˜7.55 (m, 2H), 4.72 (s, 2H), 4.58 (s, 1H), 3.99˜3.93 (m, 1H), 3.73˜3.70 (m, 5H), 3.27˜3.12 (m, 2H), 2.09˜2.02 (m, 5H), 1.94 (s, 3H), 1.85 (d, J=4.8 Hz, 1H), 1.60˜1.35 (m, 2H). MS (ES, m/z): 727 [M+H]+.

Provenance & Evidence