HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Hydroxyethyl)piperazine → HCID 57516914, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Fluoro-N-methyl-2-nitrobenzamide | HCID 44203077 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57516914 | HCID 57516914 | — |
Reaction Steps
A solution of 5-fluoro-N-methyl-2-nitrobenzamide, 1-(2-hydroxyethyl)piperazine, and Hunig's base in 20 mL of DMF was stirred at room temperature over the weekend. The resulting mixture was rotavaped to dryness, and the residue was purified by flash column SF40-150 at 2%-10% MeOH/CH2Cl2. Product came out at 7% MeOH/CH2Cl2. MS(ES) m/e 309 [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446034B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-925e971aa562492cb85f444030df8fcd |
| Source note | uspto-grants-2016_09 |