HCID 57516914, compound → 2-amino-5-[4-(2-Hydroxyethyl)-1-piperazinyl]-N-methylbenzamide

HRID 62529Notes

Reaction equation

HRID 62529 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:11]=[CH:12][C:13]([N+:20]([O-])=O)=[C:14]([CH:19]=2)[C:15]([NH:17][CH3:18])=[O:16])[CH2:6][CH2:5]1>CO.CO.C(Cl)Cl>[NH2:20][C:13]1[CH:12]=[CH:11][C:10]([N:7]2[CH2:8][CH2:9][N:4]([CH2:3][CH2:2][OH:1])[CH2:5][CH2:6]2)=[CH:19][C:14]=1[C:15]([NH:17][CH3:18])=[O:16]

Participants

4

Reactant 1

HCID 57516914HCID 57516914, compound

Product 1

HCID 575169152-amino-5-[4-(2-Hydroxyethyl)-1-piperazinyl]-N-methylbenzamide

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 21226129Dichloromethane methanolSolvent

Procedure

A solution of 5-[4-(2-hydroxyethyl)-1-piperazinyl]-N-methyl-2-nitrobenzamide 3 in 250 mL of MeOH in a 250 mL round bottom flask was stirred at room temperature under hydrogen balloon over night. The resulted mixture was filtered to get rid of the Pd catalyst. TLC in 10% MeOH/CH2Cl2 showed no more starting material and a major product. The solvent was rotavaped to dryness, and the residue was used without further purification. MS(ES) m/e 279 [M+H].

Workup

  1. filtrationThe resulted mixture was filtered
  2. customto get rid of the Pd catalyst
  3. customthe residue was used without further purification

Sources & evidence

ORD record
ord-1e0e7118770348279cda347b4a861c87
Source dataset
uspto-grants-2016_09
Patent number
US09446034B2

Reaction notes

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