2-Methoxyethylamine → 3-(benzyl(methyl)amino)-N-(2-methoxyethyl)propanamide

Participants

Reaction Conditions

Reaction Steps

To methyl 3-(benzyl(methyl)amino)propanoate (1.5 g, 7.24 mmol, 1.00 equiv) was added 2-methoxyethanamine (11 g, 146.45 mmol, 20.00 equiv) and the mixture was stirred for 2 days at 100° C. in sealed tube. The resulting mixture was concentrated under vacuum and purified via silica gel chromatography (dichloromethane/methanol 30:1) to afford 1.1 g (61%) of the product as a yellow oil.

Provenance & Evidence