HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 625451Erstellt: 25. Oktober 2026
Diisopropylethylamine → HCID 66586842, Verbindung
https://huagongshe.com/reaction/625451
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Edukt | Methylamino-PEG3-t-butyl ester | HCID 53662991 | — |
| Edukt | HCID 66586873 | HCID 66586873 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | HCID 66586842 | HCID 66586842 | 75% |
Reaktionsschritte
To a mixture of 3-((4-(diethylamino)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)benzoic acid (1.81 mmol, 1.2 g), tert-butyl 5,8,11-trioxa-2-azatetradecan-14-oate (1.9 mmol, 554 mg) and DIEA (12.67 mmol, 1.64 g) in DMF (5 mL) was added HATU (2.17 mmol, 826 mg). The mixture was stirred at 60° C. for 1 hour. The reaction mixture was diluted with ethyl acetate, washed with water (2×), sat. aqueous NaHCO3 (1×), brine (1×), dried and concentrated. The residue was purified by column to give a syrup (1.17 g, 75%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US09301951B2 |
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| Quelldatensatz | uspto-grants-2016_04 |
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| ORD ID | ord-34ffaab1352e42359b2cc653d7ddd696 |
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| Quellennotiz | uspto-grants-2016_04 |
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